Syndromes of Hormone Resistance on the Hypothalamic-Pituitary-Thyroid Axis


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Of note, growth hormone in combination with thyroxine to increase IGF1 has not led to significant improvement in height and growth [ 24 ]. Thyroxine therapy suppresses serum TSH levels and increases fT 3 above normal levels. Another potential therapeutic strategy is to develop drugs that enable nuclear receptor co-repressor NCoR to dissociate from unliganded TR or to abrogate the activity of histone deacetylases recruited by NCoR.

Additionally, no mutations in various candidate co-factors involved in TR-mediated transcription were found. It is likely that epigenetic effects that alter the expression of various genes involved in transcription may be involved, although it has not been investigated in these patients so far.

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These observations suggest that genetic and epigenetic modifiers likely play important roles in the phenotypes of affected individuals. The identification of TR mutations as causes for the two forms RTH, elucidation of their mechanism for causing resistance, correlation of genotype with phenotype, and the development of criteria for clinical diagnosis and treatment of RTH provide elegant examples of the convergence of basic, translational, and clinical research to improve the understanding and management of a genetic endocrine disorder.

Pseudohypopara-thyroidism — an example of Seabright's bantam syndrome. Aberrant alternative splicing of thyroid hormone receptor in a TSH-secreting pituitary tumor is a mechanism for hormone resistance. Mol Endocrinol. J Clin Endocrinol Metab. Genome-wide binding patterns of thyroid hormone receptor beta. PLoS One. Mechanisms of thyroid hormone receptor-specific nuclear and extra nuclear actions.

Mol Cell Endocrinol.

Resistance to thyroid hormone due to a novel mutation of thyroid hormone receptor beta gene

Baxter JD, Webb P. Thyroid hormone mimetics: potential applications in atherosclerosis, obesity and type 2 diabetes. Nat Rev Drug Discov. The variable clinical phenotype in thyroid hormone resistance syndrome. Bernal, J. Thyroid hormones in brain development and function. In Endotext, L. De Groot, P. Beck-Peccoz, G. Chrousos, K.


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  3. Vitamin E: Food Chemistry, Composition, and Analysis: Food Chemistry, Composition and Analysis (Food Science and Technology).
  4. New, R. Rebar , et al. South Dartmouth MA. Thyroid hormone transporters--functions and clinical implications. Nat Rev Endocrinol. A mutation in the thyroid hormone receptor alpha gene. N Engl J Med. Cheng SY. Isoform-dependent actions of thyroid hormone nuclear receptors: lessons from knockin mutant mice. Molecular aspects of thyroid hormone actions. Endocr Rev.

    A role for helix 3 of the TRbeta ligand-binding domain in coactivator recruitment identified by characterization of a third cluster of mutations in resistance to thyroid hormone. EMBO J. Diverse genotypes and phenotypes of three novel thyroid hormone receptor-alpha mutations. Dumitrescu, A. Impaired sensitivity to thyroid hormone: defects of transport, metabolism and action. De Groot, G.

    Syndromes of hormone resistance in the hypothalamic-pituitary-thyroid axis.

    Dungan, K. Feingold, A. Koch, M. Korbonits, R.


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    New , et al. Flamant F, Samarut J. Thyroid hormone receptors: lessons from knockout and knock-in mutant mice. Trends Endocrinol Metab. Mutations of CpG dinucleotides located in the triiodothyronine T3 -binding domain of the thyroid hormone receptor TR beta gene that appears to be devoid of natural mutations may not be detected because they are unlikely to produce the clinical phenotype of resistance to thyroid hormone. J Clin Invest. Jameson, J. Molecular mechanisms of end-organ resistance.

    Expression of mutant thyroid hormone nuclear receptors is associated with human renal clear cell carcinoma. A histone deacetylase inhibitor improves hypothyroidism caused by a TRalpha1 mutant. Hum Mol Genet.

    Thyroid Gland: Hypothalamic-Pituitary-Thyroid Axis - Role of Thyrotropin Releasing Hormone (TRH)

    Hormone and DNA binding activity of a purified human thyroid hormone nuclear receptor expressed in Escherichia Coli. J Biol Chem. Expression of mutant thyroid hormone nuclear receptors in human hepatocellular carcinoma cells. Mol Carcinog. Resistance to thyroid hormone caused by a mutation in thyroid hormone receptor TR alpha1 and TRalpha2: clinical, biochemical, and genetic analyses of three related patients.

    Lancet Diabetes Endocrinol.

    click Moran C, Chatterjee K. Resistance to thyroid hormone due to defective thyroid receptor alpha.

    Syndromes of Hormone Resistance on the Hypothalamic-Pituitary-Thyroid Axis Syndromes of Hormone Resistance on the Hypothalamic-Pituitary-Thyroid Axis
    Syndromes of Hormone Resistance on the Hypothalamic-Pituitary-Thyroid Axis Syndromes of Hormone Resistance on the Hypothalamic-Pituitary-Thyroid Axis
    Syndromes of Hormone Resistance on the Hypothalamic-Pituitary-Thyroid Axis Syndromes of Hormone Resistance on the Hypothalamic-Pituitary-Thyroid Axis
    Syndromes of Hormone Resistance on the Hypothalamic-Pituitary-Thyroid Axis Syndromes of Hormone Resistance on the Hypothalamic-Pituitary-Thyroid Axis
    Syndromes of Hormone Resistance on the Hypothalamic-Pituitary-Thyroid Axis Syndromes of Hormone Resistance on the Hypothalamic-Pituitary-Thyroid Axis

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